2-Isopropyl-4-[(N-methylamino)methyl]thiazole hydrochloride synthesis
- Product Name:2-Isopropyl-4-[(N-methylamino)methyl]thiazole hydrochloride
- CAS Number:908591-25-3
- Molecular formula:C8H15ClN2S
- Molecular Weight:206.73
154212-60-9
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908591-25-3
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Yield:-
Reaction Conditions:
with hydrogenchloride in water;isopropyl alcohol at 60; for 1 h;
Steps:
4
Hydrochloric acid (20 ml) was added to a solution of 2-Isopropyl-4-(((N- methyl)amino)methyl thiazole (9.0 g) in isopropyl alcohol (90 ml) and the resultant mixture stirred at 60°C for 1 hour. The mixture was concentrated completely under reduced pressure and the residue dissolved again in isopropyl alcohol (90 ml) at about750C. The solution was cooled to 200C and the resulting slurry stirred at 2O0C for 4 hours and then at 00C for 2 hours and filtered. The solid was washed with ethyl acetate twice (2 X 10 ml) and dried at 500C under reduced pressure for 3 hours. Yield: 8.0 g HPLC purity: 99.50%
References:
RANBAXY LABORATORIES LIMITED WO2006/90270, 2006, A1 Location in patent:Page/Page column 9