ChemicalBook CAS DataBase List 4-HYDROXY-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

4-HYDROXY-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER synthesis

5synthesis methods

Product Name:4-HYDROXY-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
CAS Number:85418-82-2
Molecular formula:C13H13NO3
Molecular Weight:231.25

106-49-0
399 suppliers
$5.00/5G

87-13-8
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$5.00/5g

4-HYDROXY-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

85418-82-2
50 suppliers
$28.60/250mg

Yield:85418-82-2 86%

Reaction Conditions:

in diphenylether at 225; for 0.0833333 h;Microwave irradiation;

Steps:

1 3.1.1. General method for the preparation of compounds 3 and 4

General procedure: Method 2. The mixture of the corresponding aniline (10 mmol)and diethyl ethoxymethylene malonate (10 mmol) in diphenyl ether (4 mL) was irradiated in monomod microwave reactor inclosed vessel at 225 C, 200 W, for 5 min. The white solid formedwas filtered off, washed with hexane and purified through recrystallizationfrom DMF to give corresponding compound.

References:

Mermer, Arif;Demirba?, Neslihan;?irin, Yakup;Uslu, Harun;?zdemir, Zeynep;Demirba?, Ahmet [Bioorganic Chemistry,2018,vol. 78,p. 236 - 248]