methyl 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylate synthesis
- Product Name:methyl 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylate
- CAS Number:851784-90-2
- Molecular formula:C11H12Cl3NO2
- Molecular Weight:296.57
851784-80-0
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Yield: 100%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane;dichloromethane at 20; for 2 h;
Steps:
3.d
d) A solution of 1. 1 (3.60 g, 10 mmol) in DCM (20 mL) was treated with HC1 in 1,4-dioxane (4.0 M, 10 mL) at room temperature. After 2 hours, the reaction was concentrated to give compound 3.5 in quantitative yield.
References:
SUNESIS PHARMACEUTICALS, INC. WO2005/44817, 2005, A1 Location in patent:Page/Page column 82-83
851784-82-2
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$11.00/250mg
74-88-4
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$15.00/10g
851784-90-2
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