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ChemicalBook CAS DataBase List (E)-N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)-4-(diMethylaMino)but-2-enaMide
848133-88-0

(E)-N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)-4-(diMethylaMino)but-2-enaMide synthesis

2synthesis methods
(E)-4-(dimethylamino)but-2-enoyl chloride

1056149-69-9
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6-AMINO-4-CHLORO-7-ETHOXYQUINOLINE-3-CARBONITRILE

848133-87-9
40 suppliers
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(E)-N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)-4-(diMethylaMino)but-2-enaMide

848133-88-0
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Yield:848133-88-0 7.97 g

Reaction Conditions:

in 1-methyl-pyrrolidin-2-one at 0 - 20; for 2.5 h;

References:

Tsou, Hwei-Ru;Overbeek-Klumpers, Elsebe G.;Hallett, William A.;Reich, Marvin F.;Floyd, M. Brawner;Johnson, Bernard D.;Michalak, Ronald S.;Nilakantan, Ramaswamy;Discafani, Carolyn;Golas, Jonathan;Rabindran, Sridhar K.;Shen, Ru;Shi, Xiaoqing;Wang, Yu-Fen;Upeslacis, Janis;Wissner, Allan [Journal of Medicinal Chemistry,2005,vol. 48,# 4,p. 1107 - 1131]