成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 8-CHLORO-2-PHENYLQUINOLINE-4-CARBOXYLIC ACID
181048-56-6

8-CHLORO-2-PHENYLQUINOLINE-4-CARBOXYLIC ACID synthesis

3synthesis methods
-

Yield:181048-56-6 36%

Reaction Conditions:

Stage #1: benzaldehyde;o-chloroanilinewith borane-THF in acetonitrile at 65; for 0.166667 h;
Stage #2: 2-oxo-propionic acid in acetonitrile; for 24 h;

Steps:

A21 Example A21
Production of 8-chloro-2-phenylquinoline-4-carboxylic acid

To a solution of 2-chloroaniline (0.522 g, 4.09 mmol) in acetonitrile (2.3 mL), benzaldehyde (0.482 g, 4.54 mmol) and boron trifluoride-tetrahydrofuran complex (125 μL, 1.14 mmol) were added, and the mixture was heated to 65° C. 10 minutes later, a solution of pyruvic acid (0.200 g, 2.27 mmol) in acetonitrile (3.8 mL) was added dropwise thereto over 3 hours. 21 hours later, the reaction solution was cooled to room temperature, and saturated aqueous sodium chloride solution was added thereto, followed by extraction with tetrahydrofuran.
The organic layer was washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then filtered, and the solvent was distilled off under reduced pressure.
The residue was purified by silica gel column chromatography (chloroform/methanol).
The obtained crude product was suspended and washed with chloroform and dried under reduced pressure to obtain the title compound (0.232 g, yield: 36%) as a faint yellow solid.
1H-NMR (400 MHz, DMSO-D6) δ: 14.2 (1H, s), 8.61 (1H, dd, J=8.5, 1.2 Hz), 8.58 (1H, s), 8.40-8.38 (2H, m), 8.07 (1H, dd, J=7.3, 1.2 Hz), 7.68 (1H, dd, J=7.3, 1.2 Hz), 7.64-7.55 (3H, m)
ESI-MS (m/z): 284, 286 (M+H)+

References:

US2022/169640,2022,A1 Location in patent:Paragraph 0201-0203