8-CHLORO-2-METHYL-4-QUINOLINOL synthesis
- Product Name:8-CHLORO-2-METHYL-4-QUINOLINOL
- CAS Number:5236-87-3
- Molecular formula:C10H8ClNO
- Molecular Weight:193.63
![Butanoic acid, 3-[(2-chlorophenyl)imino]-, ethyl ester, (3E)-](/CAS/20210305/GIF/872496-78-1.gif)
872496-78-1
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5236-87-3
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Yield:5236-87-3 77%
Reaction Conditions:
in diphenylether at 220; for 0.116667 h;
Steps:
1I.B Synthesis of P2 Moiety 8-chloro-4-hydroxy-2-methylquinoline 2I3
In a pre-heated sand bath (300-350° C.), compound 1i2 (730 mg, 3.0 mmol) in diphenyl ether (8 mL) was heated until the internal temperature reached 220° C. and that temperature was maintained for 7 minutes after which the solution was allowed to cool. Upon cooling, a beige solid crashed out and was filtered and washed with diethyl ether. After drying, the desired quinoline 1i3 was obtained as a beige solid (452 mg, 77%). MS: (M+H)+; 194, HPLC homogeneity=99%.
References:
US2006/19905,2006,A1 Location in patent:Page/Page column 28
42792-92-7
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5236-87-3
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95-51-2
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5236-87-3
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