ChemicalBook CAS DataBase List Hydrazine Carboxamide,N-{4-[4(4-methoxyphenyl)-1-pipezinyl]phenyl}

Hydrazine Carboxamide,N-{4-[4(4-methoxyphenyl)-1-pipezinyl]phenyl} synthesis

5synthesis methods

Product Name:Hydrazine Carboxamide,N-{4-[4(4-methoxyphenyl)-1-pipezinyl]phenyl}
CAS Number:74852-89-4
Molecular formula:C18H23N5O2
Molecular Weight:341.41

4-([4-(4-METHYLOXY-PHENYL)-PIPERAZIN-1-YL]-PHENYL)-CARBAMIC ACID PHENYL ESTER

74853-06-8
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Hydrazine Carboxamide,N-{4-[4(4-methoxyphenyl)-1-pipezinyl]phenyl}

74852-89-4
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Yield:74852-89-4 100%

Reaction Conditions:

with hydrazine hydrate monohydrate for 3 h;Reflux;

Steps:

1

[0072] Reduction of the nitro functionality in 5 via palladium-catalyzed transfer hydrogenation with hydrazine monohydrate provided the aniline, which was converted to triazo lone 9 through the well-characterized phenylcarbamate and semicarbazide intermediates (Scheme 2). Alkylation of the triazo lone amine with 2-bromobutane followed by removal of the methyl moiety afforded phenol 11. Base-catalyzed displacement of the tosyl moiety in 4 by the phenol provided the final des-triazole Analogue 1.

References:

WO2015/116947,2015,A1 Location in patent:Page/Page column 0072