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ChemicalBook CAS DataBase List tert-Butyl 6-[O-(2-Bromoethyl)phosphoryl)hydroxyhexanoate
73839-25-5

tert-Butyl 6-[O-(2-Bromoethyl)phosphoryl)hydroxyhexanoate synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 93 percent / H2SO4 / CH2Cl2 / Ambient temperature
2: 1) sodium formate, 2) KOH / 1) DMF, a) 110 deg C, 4h, b) RT, 2 days, 2) H2O, 30-40 deg C, 4h
3: 1) triethylamine, 2) pyridine, H2O / 1) RT, 1h, 2) RT

References:

Spande, Thomas F. [Journal of Organic Chemistry,1980,vol. 45,# 15,p. 3081 - 3084]

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