TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE synthesis
- Product Name:TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE
- CAS Number:723286-80-4
- Molecular formula:C10H15BrN4O2
- Molecular Weight:303.16
![5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/723286-79-1.gif)
723286-79-1
71 suppliers
$41.00/100mg
723286-80-4
132 suppliers
$26.00/100mg
Yield: 51%
Reaction Conditions:
with N-Bromosuccinimide;sodium hydrogencarbonate in chloroform at 0 - 20; for 2 h;
Steps:
3.4 Synthesis of tert-butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
The compound obtained in Step 3 (1 g) was dissolved in chloroform (20 mL), sodium bicarbonate (688 mg) and N- bromosuccinimide (873 mg) was added at 0 ° C., the-reaction solution was stirred for 2 hours at room temperature and extracted 3 times with chloroform after addition of water, the organic layer gave the title compound by the residue obtained, which was concentrated after drying over sodium sulfate and purified by silica gel column chromatography (693mg, 51%). LRMS (ESI) m / z 303 [M + H] +.
References:
TAIHO PHARMACEUTICAL COMPANY LIMITED;MINAMIGUCHI, KAZUHISA;OKAJIMA, SHIGEO;AOKI, SHINICHI;ASAI, MASANORI;ASAI, TAKAHIRO;YAMANAKA, HIROYOSHI;DOHI, SUGURU JP5851663, 2016, B1 Location in patent:Paragraph 0303
![1,2,4]TRIAZOLO[4,3-A]PYRAZINE](/CAS/GIF/274-82-8.gif)
274-82-8
57 suppliers
$50.00/250mg
723286-80-4
132 suppliers
$26.00/100mg
![8-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE](/CAS/GIF/68774-77-6.gif)
68774-77-6
118 suppliers
$16.00/250mg
723286-80-4
132 suppliers
$26.00/100mg