7-DEAZA-7-IODO-2'-DEOXYGUANOSINE synthesis
- Product Name:7-DEAZA-7-IODO-2'-DEOXYGUANOSINE
- CAS Number:172163-62-1
- Molecular formula:C11H13IN4O4
- Molecular Weight:392.15
![(2R,3S,5R)-5-(2-amino-5-iodo-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol](/CAS/20180703/GIF/220036-88-4.gif)
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Yield:172163-62-1 98%
Reaction Conditions:
with sodium hydroxide for 4 h;Reflux;
Steps:
1.4 Example 1: Synthesis of 7-deaza-7-iodo-2'-deoxyguanosine dG-I
Step-IV: The compound dG1-D was placed in sodium hydroxide solution (2?) And refluxed for 4 hours. After cooling, 2N hydrochloric acid solution was added and the solution The liquid pH is 6. The mixture was washed with 100 ml of dichloromethane and methanol (V: V = 1: 1). The combined organic phases were concentrated to give 255 mg of a white solid, dG-I, in 98% yield. (1H-NMR of 16-1 is shown in Fig. 7)
References:
CN103601779,2016,B Location in patent:Paragraph 0041; 0052; 0053; 0054
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![2-AMINO-4-METHOXY-7-(BETA-D-2-DEOXYRIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE](/CAS/GIF/86392-74-7.gif)
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