7-bromo-4-chloro-3-nitroquinoline synthesis
- Product Name:7-bromo-4-chloro-3-nitroquinoline
- CAS Number:723280-98-6
- Molecular formula:C9H4BrClN2O2
- Molecular Weight:287.5
723280-94-2
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723280-98-6
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Yield:723280-98-6 92%
Reaction Conditions:
with trichlorophosphate in N,N-dimethyl-formamide at 85;Inert atmosphere;
Steps:
1.2; 5.2
Step 2: To a solution of compound 5-2 (25.0 g, 93.75 mmol) was in POCh (70 mL) was added anhydrous DMF (5 mL). The reaction mixture was heated to 85 °C under nitrogen overnight. The reaction mixture was cooled to room temperature. The precipitate was collected by fdtration, washed with water and dried in high vacuum to give compound 5-3 (24.0 g, yield: 92%) as a yellow solid.
References:
WO2020/163118,2020,A1 Location in patent:Paragraph 00154-00155; 00157-00158; 00182-00184
82121-06-0
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723280-98-6
62 suppliers
$43.00/100mg