3-(DIMETHYLAMINO)-1,2-BIS(4-METHOXYPHENYL)-2-PROPEN-1-ONE synthesis
- Product Name:3-(DIMETHYLAMINO)-1,2-BIS(4-METHOXYPHENYL)-2-PROPEN-1-ONE
- CAS Number:66521-59-3
- Molecular formula:C19H21NO3
- Molecular Weight:311.37
120-44-5
131 suppliers
$10.00/1g
4637-24-5
612 suppliers
$5.00/25g
66521-59-3
15 suppliers
$181.00/500mg
Yield:66521-59-3 99%
Reaction Conditions:
in N,N-dimethyl-formamide at 100; for 2 h;Microwave irradiation;
Steps:
4.1.10. 4-Dimethylamino-3-(4-methoxyphenyl)-but-3-en-2-one (8a)
General procedure: Into a 20mL microwave vial equipped with a magnetic stir bar and crimping cap was added 4-methoxyphenylacetone (0.545g, 3.32mmol), N,N-dimethylformamide dimethyl acetal (3.18g, 26.6mmol), and dimethylformamide (5mL). The reaction mixture was heated in a microwave reactor for 2h at 100°C. The solvent was removed in vacuo, the crude mixture was diluted with water (30mL), and the aqueous solution was extracted with ethyl acetate (3×15mL). The combined organic phases were washed with aqueous lithium chloride (20mL), dried over anhydrous sodium sulfate, and concentrated in vacuo to yield an orange solid (0.721g, 99% yield)
References:
Gupton, John T.;Shimozono, Alex;Crawford, Evan;Ortolani, Joe;Clark, Evan;Mahoney, Matt;Heese, Campbell;Noble, Jeffrey;Mandry, Carlos Perez;Kanters, Rene;Dominey, Raymond N.;Goldman, Emma W.;Sikorski, James A.;Fisher, Daniel C. [Tetrahedron,2018,vol. 74,# 21,p. 2650 - 2663]
120-44-5
131 suppliers
$10.00/1g
5815-08-7
169 suppliers
$6.00/1g
66521-59-3
15 suppliers
$181.00/500mg