1-(4-FLUORO-2-NITROPHENYL)PIPERIDINE-4-CARBOXYLIC ACID synthesis
1synthesis methods
- Product Name:1-(4-FLUORO-2-NITROPHENYL)PIPERIDINE-4-CARBOXYLIC ACID
- CAS Number:648917-79-7
- Molecular formula:C12H13FN2O4
- Molecular Weight:268.24
Yield:-
Reaction Conditions:
Stage #1: isonipecotic acid;1,4-difluoro-2-nitrobenzene in 1-methyl-pyrrolidin-2-one at 80; for 2 h;
Stage #2: with hydrogenchloride in 1-methyl-pyrrolidin-2-one;water at 20;
References:
WO2004/7455,2004,A1 Location in patent:Page/Page column 36