ChemicalBook CAS DataBase List (Z)-[2-(Chloroacetamido)thiazole-4-yl]methoxyiminoacetic acid

(Z)-[2-(Chloroacetamido)thiazole-4-yl]methoxyiminoacetic acid synthesis

5synthesis methods

Product Name:(Z)-[2-(Chloroacetamido)thiazole-4-yl]methoxyiminoacetic acid
CAS Number:64486-18-6
Molecular formula:C8H8ClN3O4S
Molecular Weight:277.68

65872-41-5 Synthesis

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid

65872-41-5
339 suppliers
$6.00/5g

(Z)-[2-(Chloroacetamido)thiazole-4-yl]methoxyiminoacetic acid

64486-18-6
17 suppliers
$58.00/100mg

Yield:64486-18-6 84.7%

Steps:

2 (Example 2)

The obtained product was analyzed by HPLC and it was found that the purity was 98.20% containing impurities, i.e., (2-aminothiazole-4-yl)-(E)-methoxyiminoacetic acid in an amount of 0.23% and dithiazoleacetic acid derivative in an amount of 0.20%. By using 20.1 g (0.1 mol) of the 2-(2-aminothiazole-4-yl)-2-(Z)-methoxyiminoacetic acid, the procedure same as that of Example 1 was repeated to obtain 23.5 g of the 2-(2-chloroacetylaminothiazole-4-yl)-2-(Z)-methoxyiminoacetic acid. The yield was 84.7%. The obtained product was analyzed by HPLC and it was found that the purity was 98.60% containing impurities, i.e., 2-(2-chloroacetylaminothiazole-4-yl)-2-(E)-methoxyiminoacetic acid in an amount of 0.11% and chloroacetyldithiazoleacetic acid derivative in an amount of 0.13%.

References:

EP859002,1998,A1

65872-41-5 Synthesis

65872-41-5
339 suppliers
$6.00/5g

79-04-9 Synthesis