Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate synthesis
- Product Name:Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
- CAS Number:6386-38-5
- Molecular formula:C18H28O3
- Molecular Weight:292.41
67-56-1
759 suppliers
$7.29/5ml-f
20170-32-5
160 suppliers
$13.00/5g
6386-38-5
176 suppliers
$13.00/10g
Yield:6386-38-5 90%
Reaction Conditions:
with sulfuric acid for 16 h;Reflux;
Steps:
Typical procedure for synthesis of methyl esters
General procedure: According to a literature protocol.[1] Propanoic acid derivative (10 g) was dissolved inmethanol (80 ml) and H2SO4 (700μl, 6 mmol) added. The resulting solution was refluxed for16 h and then allowed to cool to room temperature. The reaction mixture was reduced todryness and re-dissolved in ethyl acetate (20 ml). The organic phase was washed withsaturated aqueous sodium hydrogen carbonate (10 ml), brine (10 ml) and dried over MgSO4.Removal of the solvent gave the desired methyl ester. (Note: column chromatography is oftennot required for the methyl ester starting materials).
References:
Jones, Kevin M.;Hillringhaus, Tim;Klussmann, Martin [Tetrahedron Letters,2013,vol. 54,# 25,p. 3294 - 3297] Location in patent:supporting information
5597-50-2
248 suppliers
$5.00/1g
75-65-0
760 suppliers
$10.00/10ml
6386-38-5
176 suppliers
$13.00/10g
141-32-2
566 suppliers
$18.12/100 mL
128-39-2
360 suppliers
$5.00/25g
292638-85-8
3 suppliers
inquiry
52449-44-2
2 suppliers
inquiry
6386-38-5
176 suppliers
$13.00/10g
67-56-1
759 suppliers
$7.29/5ml-f
6683-19-8
484 suppliers
$8.00/10g
6386-38-5
176 suppliers
$13.00/10g