Yield:90872-72-3 295 g

Reaction Conditions:

with sodium dithionite;potassium hydroxide in water at -20 - 75; pH=11; for 6 h;Reagent/catalyst;

Steps:

1.3; 2-4

(3) Cool down to -20°C, add 40% potassium hydroxide aqueous solution to adjust the pH to 11, add 570g solid sodium dithionite, stir the reaction at 75°C, monitor the completion of the reaction by LC-MS, after 6h, after the reaction ends, Cool to 25°C, filter the solid impurities, keep the filtrate, extract with 3L, 2L, and 1L of ethyl acetate respectively, combine the organic phases, wash twice with saturated 3L aqueous sodium chloride solution, dry the organic phase over anhydrous sodium sulfate, 40 The ethyl acetate was recovered by distillation under reduced pressure to obtain 295 g of 2-methyl-5-(pyrrolidin-2-yl)pyridine.

References:

CN114195759,2022,A Location in patent:Paragraph 0030; 0033; 0040-0045