6-METHOXY-QUINAZOLIN-4-YLAMINE synthesis
- Product Name:6-METHOXY-QUINAZOLIN-4-YLAMINE
- CAS Number:50424-28-7
- Molecular formula:C9H7ClN2O
- Molecular Weight:194.62
19181-64-7
88 suppliers
$43.00/250mg
50424-28-7
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$45.00/100mg
Yield: 91%
Reaction Conditions:
with trichlorophosphate at 120;
Steps:
1.2 Step 2: Synthesis of 4- Chloro-6-methoxyquinazoline
[0145] A solution of 6-methoxyquinazolin-4(3H)-one (3.0 g, 17.0 mmol) in POC13 (30 mL) was stirred at 120 °C overnight. Then the mixture was cooled to room temperature and evaporated. The residue was purified by silica column chromatography (PE/EtOAc from 10:1 to 5:1, v/v) to afford 4-chloro-6-methoxyquinazoline (3.0 g, 91% yield).
References:
ABM THERAPEUTICS, INC.;CHEN, Chen WO2019/60611, 2019, A1 Location in patent:Paragraph 0145
19181-64-7
88 suppliers
$43.00/250mg
50424-28-7
106 suppliers
$45.00/100mg
848438-50-6
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74-88-4
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50424-28-7
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6705-03-9
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$9.00/1g
50424-28-7
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$45.00/100mg
1882-69-5
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$6.00/5g
50424-28-7
106 suppliers
$45.00/100mg