6-Chloropurine ribonucleoside synthesis
- Product Name:6-Chloropurine ribonucleoside
- CAS Number:2004-06-0
- Molecular formula:C10H11ClN4O4
- Molecular Weight:286.67
5987-73-5
62 suppliers
$42.00/100mg
2004-06-0
213 suppliers
$8.00/1g
Yield:2004-06-0 86.4%
Reaction Conditions:
with sodium methylate in methanol
Steps:
8 6-chloro-9-β-D-ribofuranosyl-9H-purine STR15
EXAMPLE 8 6-chloro-9-β-D-ribofuranosyl-9H-purine STR15 532 g of the product of Example 7 are dissolved in 2.43 L of dry methanol. The solution is cooled at about -11° C. and 13.2 g of sodium methoxide are added under stirring. When the addition is complete the stirring is continued for minimum 1 hour. The temperature is raised to 20° C.-25° C. for minimum 2 hours. The precipitate is filtered and rinsed with methanol to afford 304.6 g of crude product. Yield: 86.4%.
References:
G. D. Searle & Co. US4992535, 1991, A
![[3,4-dibenzoyloxy-5-(6-chloropurin-9-yl)oxolan-2-yl]methyl benzoate](/CAS/20180529/GIF/3510-73-4.gif)
3510-73-4
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inquiry
2004-06-0
213 suppliers
$8.00/1g
58-63-9
644 suppliers
$5.00/25g
2004-06-0
213 suppliers
$8.00/1g
3181-38-2
168 suppliers
$5.00/250mg
2004-06-0
213 suppliers
$8.00/1g
