ChemicalBook CAS DataBase List 6-BroMo-5-Methyl-2-pyridinaMine

6-BroMo-5-Methyl-2-pyridinaMine synthesis

5synthesis methods

Product Name:6-BroMo-5-Methyl-2-pyridinaMine
CAS Number:89466-17-1
Molecular formula:C6H7BrN2
Molecular Weight:187.04

6-Bromo-5-methylpyridin-2-amine is synthesized by reacting 2-chloro-6-bromopyridine with 5-methylpyridinium iodide.

442129-37-5 Synthesis

442129-37-5
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$11.00/100mg

89466-17-1
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$24.00/250mg

Yield:89466-17-1 91%

Reaction Conditions:

with phosphorus tribromide at 140; for 6 h;

Steps:

10 Example 10:
3.4 g of chloride IA was added to 10 ml of phosphorus tribromide and heated to 140 degrees.After 6 hours of reaction, the TLC reaction was complete, dropped to ambient temperature, and slowly added to crushed ice.Add 40% sodium hydroxide to adjust the pH to 10, a large amount of solids are precipitated, filtered, and the filter cake is washed with 20 ml of water.The product IB 4g was obtained in a yield of 91%.

References:

Shandong Tefaman Pharmaceutical Co., Ltd.;Chinese Academy Of Sciences Shanghai Pharmaceutical Institute;Jiang Xiangrui;Chen Hua;Zhang Junchi;Shen Jingshan CN108658851, 2018, A Location in patent:Paragraph 0071; 0072; 0073

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