6-BROMO-2-PYRIDYL P-TOLYL KETONE synthesis
- Product Name:6-BROMO-2-PYRIDYL P-TOLYL KETONE
- CAS Number:87848-95-1
- Molecular formula:C13H10BrNO
- Molecular Weight:276.13
Yield:-
Reaction Conditions:
with hydrogenchloride;n-butyllithium in hexane;
Steps:
(Compound of Formula (I))
(Compound of Formula (I)) Butyllithium (50 mL, 1.65M in hexane) was added under nitrogen to a stirred suspension of 2,6-dibromopyridine (19.5 g) in dry ether (200 mL) at -50°. After 0.75 hr a solution of 4-tolunitrile (10 g) in ether (50 mL) was added; stirring was continued at -50° for 3 hrs. The mixture was allowed to warm to -30° and treated with hydrochloric acid (200 mL, 2M). The precipitated solid was collected, washed with water, and recrystallized from aqueous ethanol. The 2-bromo-6-(4-toluoyl)pyridine formed colourless needles (12.2 g) m.p. 97°-98°. A
References:
US4501893,1985,A
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