6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE synthesis
- Product Name:6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE
- CAS Number:143468-13-7
- Molecular formula:C7H5BrN2
- Molecular Weight:197.03
143468-12-6
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$155.00/50mg
143468-13-7
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$27.00/250mg
Yield:143468-13-7 95%
Reaction Conditions:
with water;sodium hydroxide in methanol at 20; for 2 h;
Steps:
A47.2
(b) Step 2
A solution of 1-benzoyl-6-bromo-1H-pyrrolo[2,3-b]pyridine (0.046 g, 0.15 mmol) in methanol (5.0 mL) was added with 5 N aqueous sodium hydroxide (1.0 mL), and the mixture was stirred at room temperature for 2 hours.
The solvent was evaporated under reduced pressure, the residue was extracted with diethyl ether, and then the organic layer was washed successively with water and saturated brine, and dried over anhydrous magnesium sulfate.
The solvent was evaporated under reduced pressure to obtain 6-bromo-1H-pyrrolo[2,3-b]pyridine (0.028 g, 95%).
1H NMR (300 MHz, DMSO-d6) δ 7.01 (d, J = 8.1Hz 1H), 7.46 (d, J = 8.1 Hz, 1H), 7.75 (d, J = 8.1 Hz, 1H), 8.51 (d, J = 8.1 Hz, 1H).
References:
The University of Tokyo;Riken;NAGANO Tetsuo;OKABE Takayoshi;KOJIMA Hirotatsu;SAITO Nae;NAKANO Hirofumi;ABE Masanao;TANAKA Akiko;HONMA Teruki;YOKOYAMA Shigeyuki;TSUGANEZAWA Keiko;YUKI Hitomi EP2565192, 2013, A1 Location in patent:Paragraph 0283
55052-24-9
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$80.00/5 g
143468-13-7
178 suppliers
$27.00/250mg
271-63-6
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$9.00/5g
143468-13-7
178 suppliers
$27.00/250mg