6-broMo-1,2,4-triazin-3-aMine synthesis
- Product Name:6-broMo-1,2,4-triazin-3-aMine
- CAS Number:69249-22-5
- Molecular formula:C3H3BrN4
- Molecular Weight:174.99
6-bromo-1,2,4-triazin-3-amine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly in laboratory research and development. It was prepared from 3-Amino-1,2,4-triazine and NBS by stirring in DMF for 12 h at room temperature.
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69249-22-5
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Yield:69249-22-5 81.7%
Reaction Conditions:
with N-Bromosuccinimide in N,N-dimethyl-formamide at 0 - 30; for 12 h;
Steps:
5 Example 5:Preparation of 3-amino-6-bromo-1,2,4-triazine (Compound II)
3-Amino-1,2,4-triazine (I) (0.96 g, 0.01 mol) was added to 100 mL of N,N-dimethylformamide, stirred well, and slowly dropped into 100 mL under ice bath. 0.1 mol of NBS was stirred while stirring, and the reaction was kept at 0-30 ° C for 12 hours. After the reaction was sufficiently completed, 0.3 mol of NaOH was added to the reaction, and then the reaction product was collected by filtration, and dried to obtain the product 3- Amino-6-bromo-1,2,4-triazine 1.43 g, yield 81.7%.
References:
CN108129409,2018,A Location in patent:Paragraph 0043; 0044; 0045
1120-99-6
171 suppliers
$8.00/1g
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$9.00/25ml
69249-22-5
143 suppliers
$12.00/250mg
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