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ChemicalBook CAS DataBase List 6-Amino-1-benzyl-5-methylaminouracil
72816-88-7

6-Amino-1-benzyl-5-methylaminouracil synthesis

4synthesis methods
-

Yield:72816-88-7 69%

Reaction Conditions:

Stage #1: 1-benzyl-6-aminouracilwith bromine;sodium hydrogencarbonate in methanol at 0 - 20; for 0.5 h;
Stage #2: methylamine in methanol;water at 70; for 4 h;

References:

Alphey, Magnus S.;Pirrie, Lisa;Torrie, Leah S.;Boulkeroua, Wassila Abdelli;Gardiner, Mary;Sarkar, Aurijit;Maringer, Marko;Oehlmann, Wulf;Brenk, Ruth;Scherman, Michael S.;McNeil, Michael;Rejzek, Martin;Field, Robert A.;Singh, Mahavir;Gray, David;Westwood, Nicholas J.;Naismith, James H. [ACS Chemical Biology,2013,vol. 8,# 2,p. 387 - 396]