6,7-dimethyl-1H-pteridin-4-one synthesis
- Product Name:6,7-dimethyl-1H-pteridin-4-one
- CAS Number:14684-54-9
- Molecular formula:C8H8N4O
- Molecular Weight:176.1753
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Yield:14684-54-9 72%
Reaction Conditions:
in methanol;toluene; for 1 h;Reflux;
Steps:
10
Preparation 10. 6,7-Dimethyl-pteridin-4-ol. A mixture of 6-chloropyrimidine-4,5-diamine (1.4 g, 10 mmol) and 2,3-butanedione (2.0 g, 23 mmol) in toluene (35 mL) and methanol (10 mL) was stirred at reflux for 1 h. Upon cooling, the product precipitated and was collected by suction filtration and rinsed with a MeOH/Et2O mixture (ca. 1:2), then air dried to afford 6,7-dimethylpteridin-4-ol (1.4 g, 72%) as a gold powder.
References:
US2011/54173,2011,A1 Location in patent:Page/Page column 26