成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Phosphonic acid, (2-cyclohexyl-2-oxoethyl)-, dimethyl ester
58009-66-8

Phosphonic acid, (2-cyclohexyl-2-oxoethyl)-, dimethyl ester synthesis

2synthesis methods
-

Yield:58009-66-8 97%

Reaction Conditions:

Stage #1: dimethyl methane phosphonatewith n-butyllithium in tetrahydrofuran at -78; for 0.5 h;
Stage #2: methyl cyclohexylcarboxylate in tetrahydrofuran at -78 - 0; for 1.5 h;

Steps:

86.1 Step 1: Preparation of Dimethyl (2-cyclohexyl-2-oxoethyl)phosphonate:

At about -78 C, to a solution of dimethyl methylphophonate (34.92 g, 281.69 mmol) in dry THF (150 ml) was added n-BuLi solution (116 mL, 281.69 mmol) 2.5 M in THF dropwise. The reaction mass was allowed to stir at about -78 °C for about 30 minutes and then a solution of compound methyl cyclohexanecarboxylate in THF (50 mL) was added to reaction mixture at same temperature. The resulting mixture was kept stirring at about -78 °C for about 30 minutes and then slowly warmed up to about 0 °C in about lhour. After completion, reaction mass was quenched by the addition of water ( 150 mL) and the mixture was extracted with ethyl acetate (2 x 200 mL). Combined organic layer was evaporated under reduced pressure to give compound Dimethyl (2- cyclohexyl-2-oxoethyl)phosphonate (32 g, 97%) as clear thick liquid. χΗΝΜΡν (CDCI3, 400 MHz) δ: 3.74 (s, 3H), 3.71 (s. 3H), 3.10 (s, 1H), 3.04 (s, 1H), 2.52-2.49 (m, 1H), 1.85-1.82 (m, 2H), 1.74-1.71 (m, 2H), 1.63-1.60 (m, 2H), 1.29-1.20 (m, 4H); Mass (LCMS): 235 (M + 1).

References:

WO2017/134555,2017,A1 Location in patent:Page/Page column 100; 101