1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER synthesis
- Product Name:1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER
- CAS Number:53554-29-3
- Molecular formula:C8H10N2O3S
- Molecular Weight:214.24
Yield:53554-29-3 99.7%
Reaction Conditions:
Stage #1: carbamimidothioic acid methyl esterwith sodium hydroxide in ethanol; for 0.5 h;
Stage #2: diethyl 2-ethoxymethylenemalonate in ethanol at 20; for 10 h;Time;
Steps:
1.1 A method for preparing avervavir comprising the following steps:
S1, methylthiourea sulfate(75.2g, 0.4mol)Add to a mass fraction of 16% NaOH (250 mL, 1.18 mol) and stir for 30 min.Then diethyl ethoxymethylenemalonate (103.4 g, 0.48 mol)Soluble in 160mL of ethanol and slowly drip into the reaction solution,After the completion of the dropwise addition, the reaction was carried out at room temperature for 10 hours, when a large amount of white solid precipitated,Pumping,Washed,Drying in vacuo gave a white solid (84.7 g, 99.7%);
References:
CN108707141,2018,A Location in patent:Paragraph 0027; 0028; 0029; 0038; 0047