1-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL synthesis

4synthesis methods

Product Name:1-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL
CAS Number:5334-29-2
Molecular formula:C11H7ClN4O
Molecular Weight:246.65

64-18-6 Synthesis

64-18-6
1084 suppliers
$22.12/250ML

51516-67-7 Synthesis

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE

51516-67-7
75 suppliers
$10.00/100mg

1-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL

5334-29-2
19 suppliers
$117.00/1mg

Yield:5334-29-2 73%

Reaction Conditions:

for 12 h;Reflux;

Steps:

5.1.2. General procedure for preparing 1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones (13-18)

General procedure: A mixture of 5-amino-1-phenyl-1H-pyrazole-4-carbonitriles (7-12)(0.01 mol) and 20 mL of formic acid was stirred and allowed to reflux for 12 h. The reaction mixture was poured into 50 mL of ice-cold water. The precipitate was collected by filtration and washed with water to produce 13-18 in 68-89% yield.

References:

Feitosa, Livia M.;da Silva, Edson R.;Hoelz, Lucas V.B.;Souza, Danielle L.;Come, Julio A.A.S.S.;Cardoso-Santos, Camila;Batista, Marcos M.;Soeiro, Maria de Nazare C.;Boechat;Pinheiro, Luiz C.S. [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 14,p. 3061 - 3069]

50427-79-7 Synthesis