4-AMINO-6-CHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE synthesis
- Product Name:4-AMINO-6-CHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE
- CAS Number:5305-56-6
- Molecular formula:C6H6ClN3OS
- Molecular Weight:203.65
33097-11-9
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Yield:5305-56-6 90%
Reaction Conditions:
with ammonium hydroxide in dichloromethane at 20; for 3 h;
Steps:
10 4-amino-6-chloro-2-(methylthio)pyrimidine-5-carbaldehyde (1e)
A mixture of 4,6-dichloro-2-(methylthio)pyrimidine-5-carbaldehyde (1.5 g, 6.7 mmol), NH4OH (6.0 mL) and DCM (20 mL) was stirred at rt for 3 h. The mixture was then washed with brine (50 mL x 2), dried over anhydrous Na2SO4, filtered and concentrated to afford desired product 1e as a white solid (1.3 g, yield 90%). LCMS (m/z): 203.9 [M + H] +.
References:
WO2021/71919,2021,A1 Location in patent:Paragraph 00281-00282