Yield: 100%

Reaction Conditions:

with hydroxylamine in ethanol;water for 8 h;Reflux;

Steps:

1.84
5-(Trifluoromethyl)picolinonitrile (2.0 g, 11.62 mmol) was reacted with NH₂OH (0.75 mL, 12.20 mmoL, aq.50%) in EtOH (12 mL) for 8 h as per General Procedure 1 Method 1 to provide N'-hydroxy-5-(trifluoromethyl)picolinimidamide in 100% yield (2.38 g).

References:

CINCERA THERAPEUTICS PTY LTD WO2021/12018, 2021, A1 Location in patent:Page/Page column 63; 220