ChemicalBook CAS DataBase List 5-NITRO-2-FUROYL CHLORIDE

5-NITRO-2-FUROYL CHLORIDE synthesis

4synthesis methods

Product Name:5-NITRO-2-FUROYL CHLORIDE
CAS Number:25084-14-4
Molecular formula:C5H2ClNO4
Molecular Weight:175.53

645-12-5 Synthesis

645-12-5
152 suppliers
$17.00/1g

25084-14-4
46 suppliers
$147.00/5g

Yield: 100%

Reaction Conditions:

with oxalyl dichloride in dichloromethane at 0 - 20; for 3 h;

Steps:

4 5-Nitrofuran-2-carbonyl chloride (A):
To an ice cold solution of 5-nitrofuran-2- carboxylic acid (450 mg, 2.90 mmol) in DCM (10 ml) oxalyl chloride (2.50 L, 29 mmol) was added followed by addition of catalytic amount of DMF at 0 °C and the reaction mixture was allowed to stir for 3h at room temperature. On completion, the solvent was evaporated under reduced pressure toobtain the acid chloride A with a quantitative yield (498 mg).

References:

VYOME BIOSCIENCES PVT. LTD.;SENGUPTA, Shiladitya;GHOSH, Shamik;GHOSH, Sumana;SINHA, Mau;SADHASIVAM, Suresh;BHATTACHARYYA, Anamika;MAVUDURU, Siva Ganesh;TANDON, Nupur;KUMAR, Deepak WO2017/17631, 2017, A2 Location in patent:Paragraph 00312; 00314

120-72-9 Synthesis