ChemicalBook CAS DataBase List 5-Methylthiophene-2-thiol

5-Methylthiophene-2-thiol synthesis

3synthesis methods

Product Name:5-Methylthiophene-2-thiol
CAS Number:3970-28-3
Molecular formula:
Molecular Weight:0

3128-06-1 Synthesis

3128-06-1
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3970-28-3
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Yield:3970-28-3 77%

Reaction Conditions:

with Lawessons reagent in 5,5-dimethyl-1,3-cyclohexadiene;toluene at 95; under 750.075 Torr; for 1.5 h;Inert atmosphere;Solvent;Temperature;

Steps:

9

Was added 0.23g of levulinic acid,: 20mL toluene and xylene mixture (a volume ratio of 3)And add 2 times the amount of raw material Lawson reagent,At 95 ° C, lbar nitrogen atmosphere, the reaction 1.5h, was light yellow transparent liquid. The solution was washed 3 times by volume, concentration of 5% sodium carbonate solution, by distillation under reduced pressure to give 5-methyl-thiophene-2-thiol, 77% yield.

References:

CN105566285,2016,A Location in patent:Paragraph 0019; 0046; 0047

123-76-2 Synthesis