ChemicalBook CAS DataBase List 5-Fluoro-2-Methoxy-pyridin-3-ylaMine

5-Fluoro-2-Methoxy-pyridin-3-ylaMine synthesis

4synthesis methods

Product Name:5-Fluoro-2-Methoxy-pyridin-3-ylaMine
CAS Number:1211541-93-3
Molecular formula:C6H7FN2O
Molecular Weight:142.13

1211534-27-8
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$45.00/10mg

1211541-93-3
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$56.00/100mg

Yield: 89%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in ethanol at 20; for 5 h;

Steps:

5.c
c) 5-Fluoro-2-methoxypyridin-3-amine 10% Palladium on carbon (0.300 g) was added to a solution of 5-fluoro-2-methoxy-3-nitropyridine (Preparation 5b, 0.300 g, 1.74 mmol) in ethanol (15 mL) and the reaction mixture was stirred at ambient temperature under a hydrogen atmosphere. After 5 hours, the mixture was then filtered through Celite and the filter cake was washed with ethanol. The combined filtrate and washings were concentrated to give the title compound (0.220 g, 89%) as a brown solid. LRMS (m/z): 143 (M+1)⁺. ¹H NMR δ (300 MHz, CDCl₃): 3.96 (s, 3H), 6.67 (dd, 1H), 7.39 (d, 1H).

References:

Almirall, S.A. EP2527344, 2012, A1 Location in patent:Page/Page column 22-23