5-ETHYL-THIOPHENE-2-CARBOXYLIC ACID HYDRAZIDE synthesis
- Product Name:5-ETHYL-THIOPHENE-2-CARBOXYLIC ACID HYDRAZIDE
- CAS Number:676348-42-8
- Molecular formula:C7H10N2OS
- Molecular Weight:170.23
773135-08-3
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Yield:676348-42-8 70%
Reaction Conditions:
with hydrazine hydrate in ethanol; for 12 h;Reflux;Inert atmosphere;Schlenk technique;
Steps:
General Procedure for the synthesis of the compounds 2A.
General procedure: Hydrazine monohydrate (5 mmol) was added dropwise to a solution of compounds 1A-C (1mmol) in EtOH. The mixture was refluxed for 12 h, and then the solvent was removed by rotary evaporation. The residue was treated with water and extracted with CH2Cl2. The organic layer was washed with water and dried over magnesium sulfate. The solvent was removed by rotary evaporation. The residue was purified by recrystallization.
References:
Khelladi, Mustapha;Leclerc, Nicolas;Jacquemin, Denis;De Nicola, Antoinette;Ulrich, Gilles [Tetrahedron Letters,2018,vol. 59,# 10,p. 878 - 881] Location in patent:supporting information
872-55-9
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