ChemicalBook CAS DataBase List 5α-Dihydrocortisol 21-Acetate

5α-Dihydrocortisol 21-Acetate synthesis

10synthesis methods

Product Name:5α-Dihydrocortisol 21-Acetate
CAS Number:4004-68-6
Molecular formula:C23H34O6
Molecular Weight:406.51

56736-68-6 Synthesis

(11β)-17-Dihydroxy-pregna-3,5-dien-20-one 21-(Acetyloxy)-3-ethoxy-11

56736-68-6
9 suppliers
$500.20/5MG

4004-68-6
11 suppliers
$124.90/5mg

Yield:4004-68-6 497 mg

Reaction Conditions:

Stage #1: 2-((8S,9S,10R,11S,13S,14S,17R)-3-ethoxy-11,17-dihydroxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetatewith palladium 10% on activated carbon;hydrogen in ethanol;ethyl acetate at 20;
Stage #2: with hydrogenchloride;water in ethanol;ethyl acetate;

References:

Okihara, Rika;Mitamura, Kuniko;Hasegawa, Maki;Mori, Megumi;Muto, Akina;Kakiyama, Genta;Ogawa, Shoujiro;Iida, Takashi;Shimada, Miki;Mano, Nariyasu;Ikegawa, Shigeo [Chemical and Pharmaceutical Bulletin,2010,vol. 58,# 3,p. 344 - 353] Location in patent:experimental part

50-03-3 Synthesis