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ChemicalBook CAS DataBase List 5-Chloroquinoline-2-carboxylic acid
511231-70-2

5-Chloroquinoline-2-carboxylic acid synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: iron; hydrogenchloride / ethanol; water / 1 h / 80 °C
2: Pseudomonas putida trans-o-hydroxybenzylidenepyruvate hydratase-aldolase / dimethyl sulfoxide; aq. phosphate buffer / 16 h / 20 °C / pH 6.5 / Enzymatic reaction

References:

Fansher, Douglas J.;Granger, Richard;Kaur, Satinderpal;Palmer, David R. J. [ACS Catalysis,2021,vol. 11,# 12,p. 6939 - 6943]

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