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511295-09-3

(5-CHLORO-4-METHOXY-2-METHYLPHENYL)BORONIC ACID synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: 89 percent / Br2 / CCl4 / 24 h / 20 °C
2.1: 76 percent / K2CO3 / acetone / 24 h / Heating
3.1: n-BuLi / tetrahydrofuran; hexane; diethyl ether / 0.08 h / -98 °C
3.2: B(OMe)3 / tetrahydrofuran; hexane; diethyl ether / 12 h / -98 - 20 °C
3.3: 65 percent / aq. HCl / tetrahydrofuran; hexane; diethyl ether / 20 °C

References:

Speicher, Andreas;Kolz, Juergen;Sambanje, Rufino Paulino [Synthesis,2002,# 17,p. 2503 - 2512]

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