5-CHLORO-2-NITROBENZYLAMINE synthesis
- Product Name:5-CHLORO-2-NITROBENZYLAMINE
- CAS Number:67567-44-6
- Molecular formula:C7H7ClN2O2
- Molecular Weight:186.6
Yield:67567-44-6 93%
Reaction Conditions:
in water;dimethyl sulfoxide at 20; for 2 h;
Steps:
1.5 Step 5: SNAr Reaction of (5-chloro-2-nitrophenyl)-methylamine
To a solution of (5-chloro-2-nitrophenyl)-methylamine (40 g, 208.3 mmol, 1 equiv) in DMSO (160 mL) was added 40% MeNH2 solution in water (100 mL, 1145. 6 mmol, 5.5 eq) slowly keeping the temperature below 35° C. The reaction was stirred at r.t. until the complete consumption of the starting material (>10 h). Water (400 mL) was added to the resulting orange slurry and stirred at r.t. for additional 2 h. The solid was filtered, rinsed with water (200 mL) and dried under reduced pressure at 40° C. (5-chloro-2-nitrophenyl)-methylamine (36.2 g, 93% yield, 94 A % purity) was isolated as a solid.
References:
US2013/261050,2013,A1 Location in patent:Paragraph 0151; 0152
34662-31-2
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