5-Chloro-2-(4-fluorophenyl)pyridine synthesis
- Product Name:5-Chloro-2-(4-fluorophenyl)pyridine
- CAS Number:1214327-65-7
- Molecular formula:C11H7ClFN
- Molecular Weight:207.63
460-00-4
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Yield:1214327-65-7 61.5%
Reaction Conditions:
with tetrakis-(triphenylphosphine)-palladium;potassium carbonate in ethanol;toluene; for 12 h;Reflux;
Steps:
23 Synthesis of intermediate (41)
1-bromo-4-fluorobenzene 20.0 g (114.3 mmol), 5-chloropyridin-2-yl)boronic acid 18.0 g (114.3 mmol), Pd(PPh3)4 6.6 g (5.7mmol), 2 M K2CO3 114.3 mL (228.6) mmol), 571 mL of toluene, and 286 mL of ethanol were mixed and stirred under reflux for 12 hours. After completion of the reaction, the mixture was cooled to room temperature, added with water, extracted with ethyl acetate, and the solvent was removed under reduced pressure. The obtained reaction mixture was purified by silica gel column chromatography (CHCl3) and solidified with a mixed solution (DCM/Hex) to obtain 14.6 g (yield: 61.5%) of the compound as a white solid (intermediate (41)).
References:
KR2022/30385,2022,A Location in patent:Paragraph 0655-0658
