5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID synthesis
- Product Name:5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID
- CAS Number:58483-95-7
- Molecular formula:C6H5ClN2O2
- Molecular Weight:172.57
![5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID](/CAS/GIF/171178-46-4.gif)
171178-46-4
57 suppliers
$51.00/250mg
58483-95-7
150 suppliers
$12.00/250mg
Yield:58483-95-7 87%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane
Steps:
58 4-(3-Bromoanilino)-6-chloropyrido[3,4-d]pyrimidine
5-Amino-2-chloropyridine-4-carboxylic acid. A stirred suspension of 5-[N-(tert-butoxycarbonyl)amino]-2-chloropyridine-4-carboxylic acid (1.91 g, 7 mmol) in CH2 Cl2 (200 mL) is treated slowly with trifluoroacetic acid until homogeneous (ca. 12 mL). The solution is stirred overnight and extracted with dilute NH4 OH, and the aqueous layer is then acidified with dilute HCl to gave a precipitate of 5-amino-2-chloropyridine-4-carboxylic acid (1.05 g, 87% yield). 1 H NMR (DMSO) δ 9.01 (2H, m), 8.03 (1H, s), 7.48 (1H, s).
References:
Warner-Lambert Company US5654307, 1997, A
![5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE](/CAS/GIF/171178-45-3.gif)
171178-45-3
136 suppliers
$8.00/250mg
58483-95-7
150 suppliers
$12.00/250mg
5350-93-6
421 suppliers
$6.00/5g
58483-95-7
150 suppliers
$12.00/250mg
1072-98-6
712 suppliers
$5.00/1g
58483-95-7
150 suppliers
$12.00/250mg
5326-23-8
561 suppliers
$5.00/1g
58483-95-7
150 suppliers
$12.00/250mg