ChemicalBook CAS DataBase List 5-Amino-2-chlorobenzoic acid

5-Amino-2-chlorobenzoic acid synthesis

6synthesis methods

Product Name:5-Amino-2-chlorobenzoic acid
CAS Number:89-54-3
Molecular formula:C7H6ClNO2
Molecular Weight:171.58

2516-96-3 Synthesis

2516-96-3
456 suppliers
$6.00/25g

89-54-3
251 suppliers
$13.00/5g

Yield:89-54-3 95.1%

Reaction Conditions:

with iron;ammonium chloride in ethanol;water at 78 - 80; for 5 h;

Steps:

2 Example 2
To the reaction flask was added 75 g of 2-chloro-5-nitrobenzoic acid, 59 g of iron powder, 800 ml of ethanol, 150 ml of water, 115 g of ammonium chlorideHeated to 78 ~ 80° C reflux 5h,TLC (PE / EA: 1/3) After the reaction was monitored, the filtrate was filtered while hot, washed with 150 ml of hot ethanol, and the filtrate was reduced to dryness at 60 ° C to obtain a crude product,Add 400ml ethyl acetate heating reflux beating 2h,Naturally dropped to room temperature after the salt bath cooling to 0 ~ 5° C crystallization more than 30min,Centrifuged, washed with 50 ml of ethyl acetate and dried at 50 ° C under reduced pressure to give a yellow solid 60.7 g of 2-chloro-5-aminobenzoic acid, 99.1% purity and 95.1% yield.

References:

Shandong Boyuan Pharmaceutical Co., Ltd.;Zan Jinxing;Zhao Xiwei;Liu Maosheng CN106748721, 2017, A Location in patent:Paragraph 0029; 0030

FullText

118-91-2 Synthesis