5,7-DICHLORO-3-METHYLTHIENO[3,2-B]PYRIDINE synthesis
- Product Name:5,7-DICHLORO-3-METHYLTHIENO[3,2-B]PYRIDINE
- CAS Number:952435-06-2
- Molecular formula:C8H5Cl2NS
- Molecular Weight:218.1
![3-Methylthieno[3,2-b]pyridine-5,7(4H,6H)-dione](/CAS/20200119/GIF/1356016-32-4.gif)
1356016-32-4
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952435-06-2
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Yield:-
Reaction Conditions:
with trichlorophosphate at 180; for 0.25 h;microwave;
Steps:
11.B
A mixture of 3-methyl-4H-thieno[3,2-b]pyridine-5,7-dione (0.8 g) and phosphorus oxychloride (2.5 mL) was heated to 180° C. in a microwave reactor for 15 minutes. The cooled reaction mixture was poured into a mixture of ice-water and ethyl acetate, the organic layer was separated, washed with brine, dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure. The crude residue was purified by flash chromatography (DCM) to give 5,7-dichloro-3-methyl-thieno[3,2-b]pyridine.
References:
US2012/15962,2012,A1 Location in patent:Page/Page column 65
85006-31-1
361 suppliers
$5.00/5g
952435-06-2
18 suppliers
$45.00/10mg