(4R)-4-hydroxy-1-Methyl-2-Pyrrolidinone synthesis

3synthesis methods

Product Name:(4R)-4-hydroxy-1-Methyl-2-Pyrrolidinone
CAS Number:252642-41-4
Molecular formula:C5H9NO2
Molecular Weight:115.1305

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252642-41-4
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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: triphenylphosphine / tetrahydrofuran / 1 h
1.2: 68.9 percent / tetrahydrofuran / -25 - 20 °C
2.1: 1.90 g / K₂CO₃ / methanol / 0.33 h

References:

Kanno, Osamu;Miyauchi, Masao;Shibayama, Takahiro;Ohya, Satoshi;Kawamoto, Isao [Journal of Antibiotics,1999,vol. 52,# 10,p. 900 - 907]

2-Pyrrolidinone, 1-methyl-4-[(4-nitrobenzoyl)oxy]-, (4R)-

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252642-41-4
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References

2-Pyrrolidinone, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-methyl-, (4S)-

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252642-41-4
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References