4-(Trifluoromethylthio)benzoyl chloride synthesis
- Product Name:4-(Trifluoromethylthio)benzoyl chloride
- CAS Number:330-14-3
- Molecular formula:C8H4ClF3OS
- Molecular Weight:240.63
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Yield:-
Reaction Conditions:
with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 0 - 20;
Steps:
Acyl chlorides
General procedure: The acid (5 mmol) was dissolved in anhydrous CH2Cl2 (10 mL) and DMF (a few drops) added.Oxalyl chloride (6 mmol, 1.2 equiv.) was added dropwise to the solution, that was cooled in an icewater bath. The resulting mixture was allowed to stir at room temperature for an additional 4 h andthe solvent was evaporated to afford the crude acyl chloride, which was used directly in the nextstep.
References:
Flavell, Robert R.;Liu, Jianbo;Parker, Matthew F. L.;Toste, F. Dean;Wang, Sinan;Wilson, David M. [Chem,2021,vol. 7,# 8,p. 2245 - 2255] Location in patent:supporting information
