4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE synthesis
- Product Name:4-TRIFLUOROMETHYL-THIAZOL-2-YLAMINE
- CAS Number:349-49-5
- Molecular formula:C4H3F3N2S
- Molecular Weight:168.14
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Yield: 79%
Reaction Conditions:
Stage #1:3-bromo-1,1,1-trifluoroacetone;thiourea in ethanol at 50; for 2 h;
Stage #2: with sodium hydroxide;water; pH=> 12
Steps:
21
Preparation 214-Trifluoromethyl-thiazole-2-ylamineAdd thiourea (4.0 g, 52.3 mmol) and 3-bromo-l,l,l-trifluoropropan-2-one (5.5 mL, 10 g, 52.3 mmol) to ethanol (100 mL) and heat at 50 0C for 2 h. Cool to room temperature and concentrate to dryness. Dissolve the residue in water and adjust the pH to >12 with 2 M NaOH. Extract with diethyl ether (4*). Dry the combined organic extracts with sodium sulfate, filter, and concentrate under vacuum. Purify the resulting material by silica gel chromatography (CH2Cl2) to obtain the title compound (6.9 g, 79%). ES/MS m/z 169 (M+ 1)+.
References:
ELI LILLY AND COMPANY WO2008/36579, 2008, A1 Location in patent:Page/Page column 43
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
