ChemicalBook CAS DataBase List 4-Methyl-3-cyclohexene-1-carboxylic Acid

4-Methyl-3-cyclohexene-1-carboxylic Acid synthesis

9synthesis methods

Product Name:4-Methyl-3-cyclohexene-1-carboxylic Acid
CAS Number:4342-60-3
Molecular formula:C8H12O2
Molecular Weight:140.18

79-10-7 Synthesis

79-10-7
690 suppliers
$20.50/500ml

78-79-5 Synthesis

78-79-5
256 suppliers
$14.56/25ML

4-Methyl-3-cyclohexene-1-carboxylic Acid

4342-60-3
43 suppliers
$45.00/100mg

Yield:4342-60-3 98%

Reaction Conditions:

with silver(I) acetate;boron trichloride in neat (no solvent) at 20; for 22 h;Sealed tube;Reagent/catalyst;

Steps:

3.D D. Cl2BOAc Catalyzed Cycloaddition of Acrylic Acid and Isoprene

To a 40 mL pressure vessel under air was added silver acetate (16.7mg, 0.1 mmol), acrylic acid (360 mg, 5 mmol) and isoprene (0.55 mL, 5.5 mmol). Themixture was stirred at ambient temperature for 1 min, followed by addition of BCh (1 00J.L, 0.1 mmol). The vessel was then sealed and the reaction stirred at ambient temperaturefor 22 h. After the reaction was completed, the crude was loaded directly onto a flashcolumn. Chromatographic purification (EtOAc:hexanes:AcOH=5: 100:1) gave 689 mg(98%, para/meta=96:4) of a white solid.

References:

WO2017/53652,2017,A1 Location in patent:Paragraph 00172; 00173