ChemicalBook CAS DataBase List 4-Methyl-2-nitrobenzaldehyde

4-Methyl-2-nitrobenzaldehyde synthesis

7synthesis methods

Product Name:4-Methyl-2-nitrobenzaldehyde
CAS Number:20357-22-6
Molecular formula:C8H7NO3
Molecular Weight:165.15

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20357-22-6
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Yield: 100%

Reaction Conditions:

with Dess-Martin periodane in dichloromethane at 20; for 1 h;Cooling with ice;

Steps:

A.i.3 3 Synthesis of compound TB-31-4
Accurately weigh compound TB-31-3 (600mg, 3.59mmol) into the reaction flask, dissolve it with 15ml of dichloromethane, add Dess-martin (3.35g, 7.9mmol) to the reaction flask under ice bath, and after the addition, at room temperature For the reaction, the reaction liquid was reacted to completion of the raw materials after 1 hour. The reaction was quenched by adding sodium thiosulfate aqueous solution, the pH was adjusted to 7-8 with sodium bicarbonate, a small amount of DCM was added and the mixture was stirred until the layers were separated, DCM was extracted, the DCM layer was collected, dried and concentrated to obtain 620 mg of brown liquid, which became a solid after standing. The rate is 100%.

References:

Xihua University;Chengdu University Of Traditional Chinese Medicine;Qian Shan;Cao Zhixing;Xu Shijun;Li Yuzhi;Wang Zhouyu;Li Guobo;Yang Lingling CN111689901, 2020, A Location in patent:Paragraph 0135-0136; 0141-0142

50-00-0 Synthesis