ChemicalBook CAS DataBase List 4-ISOBUTOXY-PHENYLAMINE

4-ISOBUTOXY-PHENYLAMINE synthesis

6synthesis methods

Product Name:4-ISOBUTOXY-PHENYLAMINE
CAS Number:5198-04-9
Molecular formula:C10H15NO
Molecular Weight:165.23

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Yield:5198-04-9 100%

Reaction Conditions:

with hydrogenchloride;water in methanol at 100; for 1 h;Microwave irradiation;

Steps:

25 Intermediate 25. 4-(2-methylpropoxy)aniline

Hydrochloric acid (concentrated, 1 ml) was added to N-[4-(2-methylpropoxy)- phenyl]acetamide (500 mg, 2.41 mmol) in methanol (5 ml). The mixture was heated by microwave irradiation to 100 °C for 1 hour before it was cooled to ambient temperature and concentrated. Sodium hydroxide (1M, 10 ml) was added and the resulting mixture was extracted with dichloromethane (2 x 10 ml). The organic phase was dried (phase separator) and concentrated to give the desired aniline (397 mg, quantitative).

References:

WO2019/40105,2019,A2 Location in patent:Paragraph 00262-00263

57027-72-2 Synthesis