ChemicalBook CAS DataBase List 4-IODOSTYRENE

4-IODOSTYRENE synthesis

11synthesis methods

Product Name:4-IODOSTYRENE
CAS Number:2351-50-0
Molecular formula:C8H7I
Molecular Weight:230.05

2065-66-9
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$5.00/5g

15164-44-0
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$6.00/1g

2351-50-0
50 suppliers
$45.00/10mg

Yield: 77%

Reaction Conditions:

Stage #1:methyl-triphenylphosphonium iodide with n-butyllithium in tetrahydrofuran at -78; for 0.5 h;Inert atmosphere;
Stage #2:p-(iodophenyl)carboxaldehyde in tetrahydrofuran at 20 - 55; for 5.5 h;Inert atmosphere;

Steps:

1
Under N2, 16 g (40 mmol) of methyltriphenylphosphine iodide was added to 200 mL of THF and stirred.Cool to -78 ° C, add 20 mL (48 mmol) of t-butyl lithium, react for 30 min,Continue to add 9.3g (40mmol) of p-iodobenzaldehyde, stir for 30min, and then naturally warm to room temperature.After heating to 55 ° C, the reaction was carried out for 5 h, 20 mL of a saturated ammonium chloride solution was added, and THF was distilled off.Extracted with ethyl acetate, dried, filtered, concentrated and purified by column chromatographyObtained iodine styrene, yield 77%

References:

Shijiazhuang College;Shi Lanxiang;Zhang Baohua CN108586460, 2018, A Location in patent:Paragraph 0006; 0012; 0013

1112-55-6 Synthesis