4'-(IMIDAZOL-1-YL)ACETOPHENONE synthesis

10synthesis methods

Product Name:4'-(IMIDAZOL-1-YL)ACETOPHENONE
CAS Number:10041-06-2
Molecular formula:C11H10N2O
Molecular Weight:186.21

288-32-4 Synthesis

288-32-4
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99-91-2 Synthesis

99-91-2
431 suppliers
$10.00/25g

10041-06-2
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$36.00/1g

Yield:10041-06-2 92%

Reaction Conditions:

with copper(l) iodide;potassium carbonate;1-(2-pyridyl)-3-(2-pyridyl)-1,3-propanedione in N,N-dimethyl-formamide at 20 - 110; for 18.5 h;Inert atmosphere;

Steps:

1-[4-(1H-Imidazol-1-yl)phenyl]ethanone (3)
General procedure: The compound was prepared according to a modified literature procedure.22 A mixture of imidazole (1.021 g, 15 mmol), anhydrous potassium carbonate (2.76 g, 20 mmol), copper iodide (0.119 g,1.0 mmol), 1,3-di(pyridin-2-yl)propane-1,3-dione (10.0 mmol), 4-haloacetophenone (10.0 mmol) and DMF (15 mL) was stirred for 30 min at room temperature under a nitrogen atmosphere. This wa sfollowed by heating at 110 °C for 12-18 h. After the completion of the reaction (as indicated by TLC), the contents were cooled to room temperature and passed through a plug of Celite. The filtrate was diluted with ethyl acetate (50 mL) and washed three times with saturated brine (10 mL each time). Treatment of the organic layer with activated charcoal and evaporation of the solvent under vacuum afforded the product: Yield (see Table 1); m.p. 115-116 °C (lit.22 114-116 °C).

References:

Hussain, Tanvir;Zia-Ur-Rehman, Muhammad;Zaheer, Muhammad;Ashraf, Chouhdary Muhammad;Bolte, Michael [Journal of Chemical Research,2016,vol. 40,# 4,p. 199 - 204]

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288-32-4 Synthesis

288-32-4
1013 suppliers
$5.00/25g