4-HYDROXYMETHYL-5-METHYLIMIDAZOLE synthesis
- Product Name:4-HYDROXYMETHYL-5-METHYLIMIDAZOLE
- CAS Number:29636-87-1
- Molecular formula:C5H8N2O
- Molecular Weight:112.13
51605-32-4
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$6.00/1g
29636-87-1
139 suppliers
$30.00/5g
Yield:-
Reaction Conditions:
with hydrogenchloride in tetrahydrofuran;ethanol
Steps:
22.A A.
A. 5-Methyl-4-hydroxymethylimidazole To a suspension of lithium aluminum hydride (5.4 g, 142 mmol) in THF (200 mL) at 0°C was added ethyl 4-methylimidazole-5-carboxylate (15.4 g, 100 mmol) in portions as a slurry in THF (100 mL). The solution was stirred 24 hours at room temperature, concentrated HCl was added and the organic solvent was evaporated. Absolute ethanol was added, and the mixture was heated to boiling and filtered hot through Celite. The filtrate was evaporated to afford 23 g of Compound 1 (>>100%) as a brown semisolid. 13C (CD30D) 9.27, 53.94, 127.92, 130.10, 133.67 ppm.
References:
BRISTOL-MYERS SQUIBB COMPANY EP675112, 1995, A1
51605-32-4
160 suppliers
$6.00/1g
29636-87-1
139 suppliers
$30.00/5g
50-00-0
865 suppliers
$10.00/25g
51605-32-4
160 suppliers
$6.00/1g
29636-87-1
139 suppliers
$30.00/5g
